References




Comments

Post a Comment

Popular posts from this blog

49)Republic Day Parade 2019: Indias rich cultural diversity with display at Rajpath; 10 tips

India Republic Day -- In Indias 70th Republic Time Saturday the annual attend in the national capital displayed the countrys rich ethnic heritage and traditions. The central theme of the tableaux displayed was Mahatma Gandhi as 2019 marks all four of his 150th beginning anniversary. The might of the Indian military was upon full display and in special womens power. Before the attend celebrations kicked off having Prime Minister Narendra Modi paying homage to the martyrs by laying a floral wreath at Amar Jawan Jyoti. At Rajpath the Prime Minister received President Memory Nath Kovind and Southern Africas President Cyril Ramaphosa who was the Chief Guest on Indias Republic Day 2019 event. President Kovind hoisted the tricolour as the country wide anthem played and a 21-gun salute was fired simply by seven cannons of 2281 Field Regiment. Republic Time Parade 2019 * Assam Rifles tableau: Participating in typically the Republic Day parade for the first time in history the Assam Sniper ...
Read more

Nature as source

Image
Traditionally, many drugs and other chemicals with biological activity have been discovered by studying chemicals that organisms create to affect the activity of other organisms for survival. Despite the rise of combinatorial chemistry as an integral part of lead discovery process, natural products still play a major role as starting material for drug discovery. A 2007 report found that of the 974 small molecule new chemical entities developed between 1981 and 2006, 63% were natural derived or semisynthetic derivatives of natural products. For certain therapy areas, such as antimicrobials, antineoplastics, antihypertensive and anti-inflammatory drugs, the numbers were higher. citation needed In many cases, these products have been used traditionally for many years. citation needed Natural products may be useful as a source of novel chemical structures for modern techniques of development of antibacterial therapies. Plant-derived edit Many secondary metabolites produced by plants have...
Read more

Drug discovery

Image
In the fields of medicine, biotechnology and pharmacology, drug discovery is the process by which new candidate medications are discovered. Historically, drugs were discovered by identifying the active ingredient from traditional remedies or by serendipitous discovery, as with penicillin. More recently, chemical libraries of synthetic small molecules, natural products or extracts were screened in intact cells or whole organisms to identify substances that had a desirable therapeutic effect in a process known as classical pharmacology. After sequencing of the human genome allowed rapid cloning and synthesis of large quantities of purified proteins, it has become common practice to use high throughput screening of large compounds libraries against isolated biological targets which are hypothesized to be disease-modifying in a process known as reverse pharmacology. Hits from these screens are then tested in cells and then in animals for efficacy. Modern drug discovery involves the identi...
Read more